Following its support for groundbreaking achievements in multiple research fields, IGT® has once again assisted clients in publishing a significant research paper in the journal Genomics, Proteomics & Bioinformatics, bringing new breakthroughs to genetic research on the Han ethnicity.
On June 4, 2025, a multi-institutional team including Academician Liu Chao from the Guangdong Provincial Center for Drug Experimentation Technology (Guangdong Branch of the National Drug Laboratory), Professor Nie Shengjie from the School of Forensic Medicine, Kunming Medical University, Associate Researcher He Guanglin from the Archaeological Science Center/West China Institute of Rare Diseases, Sichuan University, and Associate Professor Wang Mengge from the Department of Forensic Medicine, School of Basic Medical Sciences, Chongqing Medical University, published a paper entitled YanHuang Paternal Genomic Resource Suggested a Weakly-Differentiated Multi-Source Admixture Model for the Formation of Han's Founding Ancestral Lineages in the journal Genomics, Proteomics & Bioinformatics.
Based on the independently developed high-resolution SNP genotyping system (YHseqY3000), the research team performed Y-chromosome targeted capture sequencing on 5,020 Han male individuals from 29 provinces in China. Subsequently, by integrating methods such as principal component analysis and population genetic structure analysis, they revealed the unique evolutionary pattern of multi-source admixture and weak differentiation in the paternal genomes of the Han ethnicity.
The study found that multiple founding paternal lineages originating from Ancient West Eurasia, Siberia, and East Asia have made significant contributions to the Han gene pool. Additionally, the study proposed the "Weakly-Differentiated Multi-Source Admixture (WDMSA)" model, clarifying the influence of multiple ancestral sources on the formation of the modern Han ethnicity. This provides solid genetic evidence for in-depth analysis of the paternal genetic diversity and evolutionary history of the Han ethnicity. IGT® is honored to have provided the multiplex MultipSeq Custom Panel for this project, assisting the research team in accurately capturing genomic variations.
Original Link: https://doi.org/10.1093/gpbjnl/qzaf049
Related Products from IGT
IGT has been deeply engaged in the field of multiplex PCR targeted capture for many years. Its independently developed MultipSeq® technology platform can fulfill customers' personalized Panel customization on demand, supporting rapid design, kit conversion, and testing services for loci ranging from as few as dozens to over a thousand across multiple species. It has successfully provided sample identification kit development and technical solutions to over a hundred customers in the biomedical, agricultural, animal husbandry, and forensic fields. IGT will continue to maintain its advantages and continuously lead the expansion of new applications of multiplex PCR.
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