iGeneTech Supports Client's Nature Communications Study: Deciphering Heterogeneity and Immune Remodeling of Pituitary Neuroendocrine Tumors

Pituitary neuroendocrine tumors (PitNETs) are invasive and aggressive, but the underlying mechanisms remain unclear.

On May 30, 2025, multidisciplinary experts from Peking University, Peking Union Medical College, and other institutions published an important research achievement in Nature Communications as co-corresponding authors. Through single-cell RNA sequencing and spatial transcriptomics analysis, the study revealed the tumor heterogeneity and immune microenvironment remodeling of PitNETs, providing new insights into the molecular mechanisms of tumor progression.

The research team included 57 tissue samples, analyzing over 177,000 cells and 35,000 spots. The findings not only uncovered the tumor heterogeneity of PitNETs but also identified the enrichment of SPP1+ tumor-associated macrophages (TAMs) in invasive tumors, offering new ideas for clinical diagnosis and treatment. iGeneTech® was honored to provide whole exome probes and capture reagents for this study.

Figure 1 Single-cell transcriptomic and spatial profiling of PitNETs (from Nature Communications)

Source Link: https://www.nature.com/articles/s41467-025-60028-5

Recommended iGeneTech Products: 
Combining iGeneTech's capture technology with single-cell sequencing can effectively enhance mutation detection and precisely localize to cell subsets, providing more intuitive data for clonal evolution and tumor regulation analysis.

In 2025, iGeneTech will grandly launch the newly upgraded "AIExome V5" series. With superior performance and innovative technologies, the series offers users more flexible configuration options and precise technical support.