TargetSeq® Lymphoma SV Panel

Coverage

This product replaces the traditional FISH method with probe capture technology, encompassing IGH class switch regions involved in common structural variations and providing high-tiling coverage of the Major translocation cluster（MTC） regions of genes such as MYC, BCL2, and BCL6.

Detection Range

SV

Recommend Sequencing Data

5 Gb raw bases

Applications

In high-grade B-cell lymphomas, rearrangements of genes such as MYC, BCL2, or BCL6 with the super-enhancer (IGH) lead to oncogene overexpression and/or amplification, giving rise to a distinct subgroup characterized by high aggressiveness and poor prognosis.