Lymphoma SV Panel - iGeneTech Bioscience Co., Ltd.

Overview

Ordering Info

Resources

Overview

In high-grade B-cell lymphoma, rearrangements between genes such as MYC, BCL2, or BCL6 and super-enhancers (IGH) are relatively common. Although such structural variations do not form specific fusion proteins, they lead to overexpression/amplification of proto-oncogenes due to special chromosomal-level structural abnormalities, resulting in a special subgroup with high aggressiveness and poor prognosis. This product replaces the traditional FISH method through a probe capture approach, including the IGH class switch regions involved in common structural variations, and provides dense coverage of the MTC regions of genes such as MYC, BCL2, and BCL6, thereby offering a basis for clinical targeted molecular typing and prognostic testing.

Product Specifications

Coverage Size	7.7 Mb
Coverage	This product replaces the traditional FISH method with probe capture technology, encompassing IGH class switch regions involved in common structural variations and providing high-tiling coverage of the Major translocation cluster（MTC） regions of genes such as MYC, BCL2, and BCL6.
Detection Range	SV
Recommend Sequencing Data	5 Gb raw bases
Applications	In high-grade B-cell lymphomas, rearrangements of genes such as MYC, BCL2, or BCL6 with the super-enhancer (IGH) lead to oncogene overexpression and/or amplification, giving rise to a distinct subgroup characterized by high aggressiveness and poor prognosis.

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Learn More About TargetSeq® Lymphoma SV Panel

Ordering Info

TargetSeq® Lymphoma SV Panel

Product Name	Set	Cat. No
TargetSeq® Lymphoma SV Panel	4 rxn	PH2001700
	24 rxn	PH2001705
	96 rxn	PH2001702

Resources

bed File

TargetSeq® Lymphoma SV Panel bed file
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Demo DataSet

TargetSeq® Lymphoma SV Panel demo data
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