iGeneTech Bioscience Co., Ltd.
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Oncogenic Pathogens Panel

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Overview
Product Specification
References

Overview

Oncogenic pathogens refer to microorganisms that can establish chronic infections in the human body, induce persistent inflammation, or directly integrate into the host genome, thereby promoting genetic mutations, uncontrolled cell proliferation, and ultimately leading to the development of malignant tumors. They are primarily transmitted via blood, body fluids, or direct mucosal contact, and can not only cause local lesions at the infection site but also induce preneoplastic lesions and cancer through chronic damage to tissues such as the liver, skin/mucosa.


Leveraging its proprietary TargetSeq® liquid-phase probe hybridization capture technology and unique microbial probe design strategies, iGeneTech is dedicated to addressing critical issues such as viral variant monitoring, low-abundance viral sample detection, and host origin tracing. The company has currently launched multiple whole-genome detection kits for oncogenic pathogens.


Product Specification

Product NamePathogen Species DetailstxidCoverage SizeNumber of Reference SequencesNumber of Probes
HBV PanelHepatitis B virus104073.2 kb1956110633
HPV Panelhuman Papillomavirus105667.3 kb3266158121
EBV Panelhuman gammaherpesvirus 410376171.8 kb48525331


Ordering Info

Product NameSetCat. No
HBV Panel16 rxnPH2001301
24 rxnPH2001305
96 rxnPH2001302
HPV Panel16 rxnPH2001191
24 rxnPH2001195
96 rxnPH2001192
EBV Panel16 rxnPH2003991
24 rxnPH2003995
96 rxnPH2003992


References

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4.Chen C, Li J, et al. MINERVA: A Facile Strategy for SARS-CoV-2 Whole-Genome Deep Sequencing of Clinical Samples. Mol Cell. 2020 Dec 17;80(6):1123-1134.e4.

5.Xu Y, Kang L, et al. Dynamics of severe acute respiratory syndrome coronavirus 2 genome variants in the feces during convalescence. J Genet Genomics. 2020 Oct 20;47(10):610-617.

6.Wu X, Ning C, et al. A 3,000-year-old, basal S. enterica lineage from Bronze Age Xinjiang suggests spread along the Proto-Silk Road. PLoS Pathog. 2021 Sep 21;17(9):e1009886.

7.Zhang J, Ding N, et al. Phylogenomic tracing of asymptomatic transmission in a COVID-19 outbreak. Innovation (Camb). 2021 May 28;2(2):100099.

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11.Li P, Ke Y, et al. Targeted screening of genetic associations with COVID-19 susceptibility and severity. Front Genet. 2022 Nov 30;13:1073880.

12.Pu R, Liu W, et al. The Effects and Underlying Mechanisms of Hepatitis B Virus X Gene Mutants on the Development of Hepatocellular Carcinoma. Front Oncol. 2022 Feb 10;12:836517.

13.Zhang M, Zhang H, et al. Liver biopsy of chronic hepatitis B patients indicates HBV integration profile may complicate the endpoint and effect of entecavir treatment. Antiviral Res. 2022 Aug;204:105363.

14.Shen C, Li Y, et al. HTLV-1 infection of donor-derived T cells might promote acute graft-versus-host disease following liver transplantation. Nat Commun. 2022 Nov 30;13(1):7368.

15.Liu W, Cai S, et al. HBV preS Mutations Promote Hepatocarcinogenesis by Inducing Endoplasmic Reticulum Stress and Upregulating Inflammatory Signaling. Cancers (Basel). 2022 Jul 4;14(13):3274.

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17.Wang Y, Nan X, et al. Consumption of Supplementary Inulin Modulates Milk Microbiota and Metabolites in Dairy Cows with Subclinical Mastitis. Appl Environ Microbiol. 2022 Feb 22;88(4):e0205921.

18.Lang B, Cao C, et al. Genomic alterations related to HPV infection status in a cohort of Chinese prostate cancer patients. Eur J Med Res. 2023 Jul 17;28(1):239.

19.Adeola AC, Luka PD, et al. Target capture sequencing for the first Nigerian genotype I ASFV genome. Microb Genom. 2023 Jul;9(7):mgen001069.

20.Sun B, Andrades Valtueña A, et al. Origin and dispersal history of Hepatitis B virus in Eastern Eurasia. Nat Commun. 2024 Apr 5;15(1):2951.

21.Wang Z, Liu C, et al. Long-read sequencing reveals the structural complexity of genomic integration of HPV DNA in cervical cancer cell lines. BMC Genomics. 2024 Feb 20;25(1):198.

22.Yang Z, Zeng J, et al. Detection of HBV DNA integration in plasma cell-free DNA of different HBV diseases utilizing DNA capture strategy. Virol Sin. 2024 Aug;39(4):655-666.