MRD Panel Design - iGeneTech Bioscience Co., Ltd.

Overview

Performance

Ordering Info

Resources

Overview

Based on tumor-informed assays, combined with independently developed hybridization capture systems and high-throughput MRD Panel synthesis, we have launched a comprehensive MRD hybridization capture reagent set—including hybridization capture reagents, blocking sequences, and capture beads. Paired with free customized MRD Panels, this solution delivers a cost-effective and highly stable MRD detection protocol, promoting the popularization of MRD detection in clinical applications.

Advantages

Full-process supporting reagents—ensuring stable and efficient operation throughout the entire workflow
Highly compatible hybridization capture reagents—compatible with all probe types, and applicable to multiple hybridization and rapid hybridization scenarios
High-throughput MRD Panel customization—zero-cost support for large sample volume requirements
Increased monitoring sites for personalized MRD Panels—significantly enhanced detection sensitivity

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Performance

Capture Performance of MRD Panels of Different Sizes

Capture_Performance_of_MRD_Panels_of_Different_Sizes_01.png

Figure 1. Statistical Testing Results of MRD Panels by Probe Count

Based on iGeneTech’s MRD Panel comprehensive solution, 33 distinct synthesized MRD Panels (covering 15 to 150 loci) were tested for capture performance. All tested MRD Panels demonstrated excellent capture performance.

Probe Storage Stability Test

Capture_Performance_of_MRD_Panels_of_Different_Sizes_02.png

Figure 2. Data Performance of MRD Panel Probe Storage Stability

A 34-locus MRD Panel was used for the test, with a single-hybridization library input amount of 750 ng, and sequencing was performed on the NovaSeq 6000 platform using the PE150 strategy. Capture tests were conducted on the MRD Panel probes after 3 and 7 days of storage at room temperature, while the control probes were stored at -20 ℃. The test data demonstrated that the MRD Panel maintained stable capture performance after 3–7 days of storage at room temperature.

Probe Freeze-Thaw Stability Test

Capture_Performance_of_MRD_Panels_of_Different_Sizes_03.png Figure 3. Data Performance of MRD Panel Probe Freeze-Thaw Stability

A 25-locus MRD Panel was used for the test, with a single-hybridization library input amount of 750 ng, and sequencing was performed on the NovaSeq 6000 platform using the PE150 strategy. Capture tests were conducted on the MRD Panel probes after 10 and 20 repeated freeze-thaw cycles, while the control probes were stored at -20℃. The test data demonstrated that the MRD Panel maintained stable capture performance after 10 and 20 repeated freeze-thaw cycles.

Ordering Info

MRD Panel Design

Product Name	Set	Cat. No
Tumor-informed MRD Research Kit v2.0 (for Illumina) *	24 rxn	C11594
Tumor-informed MRD Research Kit v2.0 (for Illumina) *	96 rxn	C11592

*The shipping list includes hybridization capture reagents, blocking sequences, and capture beads.

Resources

bed File

Tumor-informed MRD Research Kit v2.0 bed file
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Demo DataSet

Tumor-informed MRD Research Kit v2.0 demo data
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MRD Design Website

MRD Design Website
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